Targeted RNAi of BIRC5/Survivin Using Antibody-Conjugated Poly(Propylene Imine)-Based Polyplexes Inhibits Growth of PSCA-Positive Tumors

• Main Authors: Willi Jugel (Author), Achim Aigner (Author), Susanne Michen (Author), Alexander Hagstotz (Author), Alexander Ewe (Author), Dietmar Appelhans (Author), Gabriele Schackert (Author), Achim Temme (Author), Stefanie Tietze (Author)
• Format: Book
• Published: MDPI AG, 2021-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Delivery of siRNAs for the treatment of tumors critically depends on the development of efficient nucleic acid carrier systems. The complexation of dendritic polymers (dendrimers) results in nanoparticles, called dendriplexes, that protect siRNA from degradation and mediate non-specific cellular upt...