Efficient Messenger RNA Delivery to the Kidney Using Renal Pelvis Injection in Mice

• Prif Awduron: Natsuko Oyama (Awdur), Maho Kawaguchi (Awdur), Keiji Itaka (Awdur), Shigeru Kawakami (Awdur)
• Fformat: Llyfr
• Cyhoeddwyd: MDPI AG, 2021-10-01T00:00:00Z.
• Pynciau: article
• Mynediad Ar-lein: Connect to this object online.

Renal dysfunction is often associated with the inflammatory cascade, leading to non-reversible nephrofibrosis. Gene therapy has the ability to treat the pathology. However, the difficulty in introducing genes into the kidney, via either viral vectors or plasmid DNA (pDNA), has hampered its extensive...