Development of a humanized antibody with high therapeutic potential against dengue virus type 2.

• Main Authors: Pi-Chun Li (Author), Mei-Ying Liao (Author), Ping-Chang Cheng (Author), Jian-Jong Liang (Author), I-Ju Liu (Author), Chien-Yu Chiu (Author), Yi-Ling Lin (Author), Gwong-Jen J Chang (Author), Han-Chung Wu (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2012-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND: Dengue virus (DENV) is a significant public health threat in tropical and subtropical regions of the world. A therapeutic antibody against the viral envelope (E) protein represents a promising immunotherapy for disease control. METHODOLOGY/PRINCIPAL FINDINGS: We generated seventeen novel...