Altered patterns of gene expression underlying the enhanced immunogenicity of radiation-attenuated schistosomes.

• Main Authors: Gary P Dillon (Author), Theresa Feltwell (Author), Jason Skelton (Author), Patricia S Coulson (Author), R Alan Wilson (Author), Alasdair C Ivens (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2008-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Schistosome cercariae only elicit high levels of protective immunity against a challenge infection if they are optimally attenuated by exposure to ionising radiation that truncates their migration in the lungs. However, the underlying molecular mechanisms responsible for the altered phenotype of the...