Impact of Hot-Melt Extrusion on Glibenclamide's Physical and Chemical States and Dissolution Behavior: Case Studies with Three Polymer Blend Matrices

• Hoofdauteurs: Nina Zupan (Auteur), Ines Yous (Auteur), Florence Danede (Auteur), Jeremy Verin (Auteur), Mostafa Kouach (Auteur), Catherine Foulon (Auteur), Emeline Dudognon (Auteur), Susanne Florin Muschert (Auteur)
• Formaat: Boek
• Gepubliceerd in: MDPI AG, 2024-08-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

This research work dives into the complexity of hot-melt extrusion (HME) and its influence on drug stability, focusing on solid dispersions containing 30% of glibenclamide and three 50:50 polymer blends. The polymers used in the study are Ethocel Standard 10 Premium, Kollidon SR and Affinisol HPMC H...