Impact of Hot-Melt Extrusion on Glibenclamide's Physical and Chemical States and Dissolution Behavior: Case Studies with Three Polymer Blend Matrices

• Главные авторы: Nina Zupan (Автор), Ines Yous (Автор), Florence Danede (Автор), Jeremy Verin (Автор), Mostafa Kouach (Автор), Catherine Foulon (Автор), Emeline Dudognon (Автор), Susanne Florin Muschert (Автор)
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• Опубликовано: MDPI AG, 2024-08-01T00:00:00Z.
• Предметы: article
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This research work dives into the complexity of hot-melt extrusion (HME) and its influence on drug stability, focusing on solid dispersions containing 30% of glibenclamide and three 50:50 polymer blends. The polymers used in the study are Ethocel Standard 10 Premium, Kollidon SR and Affinisol HPMC H...