Impact of Hot-Melt Extrusion on Glibenclamide's Physical and Chemical States and Dissolution Behavior: Case Studies with Three Polymer Blend Matrices

• मुख्य लेखकों: Nina Zupan (लेखक), Ines Yous (लेखक), Florence Danede (लेखक), Jeremy Verin (लेखक), Mostafa Kouach (लेखक), Catherine Foulon (लेखक), Emeline Dudognon (लेखक), Susanne Florin Muschert (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: MDPI AG, 2024-08-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

This research work dives into the complexity of hot-melt extrusion (HME) and its influence on drug stability, focusing on solid dispersions containing 30% of glibenclamide and three 50:50 polymer blends. The polymers used in the study are Ethocel Standard 10 Premium, Kollidon SR and Affinisol HPMC H...