Impact of Hot-Melt Extrusion on Glibenclamide's Physical and Chemical States and Dissolution Behavior: Case Studies with Three Polymer Blend Matrices

• Main Authors: Nina Zupan (Author), Ines Yous (Author), Florence Danede (Author), Jeremy Verin (Author), Mostafa Kouach (Author), Catherine Foulon (Author), Emeline Dudognon (Author), Susanne Florin Muschert (Author)
• Format: Book
• Published: MDPI AG, 2024-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

This research work dives into the complexity of hot-melt extrusion (HME) and its influence on drug stability, focusing on solid dispersions containing 30% of glibenclamide and three 50:50 polymer blends. The polymers used in the study are Ethocel Standard 10 Premium, Kollidon SR and Affinisol HPMC H...