Lactate as a Potential Biomarker of Sepsis in a Rat Cecal Ligation and Puncture Model

• Main Authors: Xiaozhu Zhai (Author), Zhengfei Yang (Author), Guanghui Zheng (Author), Tao Yu (Author), Peng Wang (Author), Xuefen Liu (Author), Qin Ling (Author), Longyuan Jiang (Author), Wanchun Tang (Author)
• Format: Book
• Published: Hindawi Limited, 2018-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We attempted to investigate whether blood lactate is a useful biomarker for sepsis in a rat cecal ligation and puncture (CLP) model. Male Sprague-Dawley rats underwent approximately 75% cecum ligation and two punctures to induce high-grade sepsis. A lactate of 1.64 mmol/L (Youden score of 0.722) was...