Regulation of High-Altitude Hypoxia on the Transcription of CYP450 and UGT1A1 Mediated by PXR and CAR

• Glavni autori: Ya-bin Duan (Autor), Jun-bo Zhu (Autor), Jian-xin Yang (Autor), Gui-qin Liu (Autor), Xue Bai (Autor), Ning Qu (Autor), Xue-jun Wang (Autor), Xiang-yang Li (Autor)
• Format: Knjiga
• Izdano: Frontiers Media S.A., 2020-09-01T00:00:00Z.
• Teme: article
• Online pristup: Connect to this object online.

Little is known about what roles the pregnane X receptor (PXR) and constitutive androstane receptor (CAR) play in drug metabolism in high-altitude hypoxia. Likewise, the potential interaction of nuclear receptors and drug metabolism enzymes during drug metabolism of high-altitude hypoxia is not full...