Regulation of High-Altitude Hypoxia on the Transcription of CYP450 and UGT1A1 Mediated by PXR and CAR

• Main Authors: Ya-bin Duan (Author), Jun-bo Zhu (Author), Jian-xin Yang (Author), Gui-qin Liu (Author), Xue Bai (Author), Ning Qu (Author), Xue-jun Wang (Author), Xiang-yang Li (Author)
• Format: Book
• Published: Frontiers Media S.A., 2020-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Little is known about what roles the pregnane X receptor (PXR) and constitutive androstane receptor (CAR) play in drug metabolism in high-altitude hypoxia. Likewise, the potential interaction of nuclear receptors and drug metabolism enzymes during drug metabolism of high-altitude hypoxia is not full...