Limited Sampling Modeling for Estimation of Phenotypic Metrics for CYP Enzymes and the ABCB1 Transporter Using a Cocktail Approach

• Egile Nagusiak: Eduardo Barbosa Coelho (Egilea), Diego Alberto Ciscato Cusinato (Egilea), João Paulo Ximenez (Egilea), Vera Lucia Lanchote (Egilea), Claudio José Struchiner (Egilea), Guilherme Suarez-Kurtz (Egilea)
• Formatua: Liburua
• Argitaratua: Frontiers Media S.A., 2020-02-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Plasma concentration data points (n = 2,640) from 16 healthy adults were used to develop and validate limited sampling strategies (LSS) for estimation of phenotypic metrics for CYP enzymes and the ABCB1 transporter, using a cocktail of subtherapeutic doses of the selective probes caffeine (CYP1A2),...