Surgical procedure of intratympanic injection and inner ear pharmacokinetics simulation in domestic pigs

• Main Authors: Adele Moatti (Author), Shannon Connard (Author), Novietta De Britto (Author), William A. Dunn (Author), Srishti Rastogi (Author), Mani Rai (Author), Lauren V. Schnabel (Author), Frances S. Ligler (Author), Kendall A. Hutson (Author), Douglas C. Fitzpatrick (Author), Alec Salt (Author), Carlton J. Zdanski (Author), Alon Greenbaum (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Introduction: One major obstacle in validating drugs for the treatment or prevention of hearing loss is the limited data available on the distribution and concentration of drugs in the human inner ear. Although small animal models offer some insights into inner ear pharmacokinetics, their smaller or...