Role of Cytosolic Serine Hydroxymethyl Transferase 1 (SHMT1) in Phosphate-Induced Vascular Smooth Muscle Cell Calcification

• Main Authors: Beate Boehme (Author), Nadeshda Schelski (Author), Manousos Makridakis (Author), Laura Henze (Author), Antonia Vlahou (Author), Florian Lang (Author), Burkert Pieske (Author), Ioana Alesutan (Author), Jakob Voelkl (Author)
• Format: Book
• Published: Karger Publishers, 2018-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background/Aims: Hyperphosphatemia promotes medial vascular calcification, at least partly, by induction of osteo-/chondrogenic transdifferentiation of vascular smooth muscle cells (VSMCs). The complex signaling pathways regulating this process are still incompletely understood. The present study in...