Population pharmacokinetics and individualized dosing of vancomycin for critically ill patients receiving continuous renal replacement therapy: the role of residual diuresis

• Main Authors: Zhenwei Yu (Author), Jieqiong Liu (Author), Haitao Yu (Author), Ling Zhou (Author), Jianping Zhu (Author), Gang Liang (Author), Yi Yang (Author), Ying Zheng (Author), Yun Han (Author), Junjun Xu (Author), Gang Han (Author), Lingyan Yu (Author), Yuhua Zhao (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Vancomycin dosing is difficult in critically ill patients receiving continuous renal replacement therapy (CRRT). Previous population pharmacokinetic (PopPK) models seldom consider the effect of residual diuresis, a significant factor of elimination, and thus have poor external utility. T...