Icariin Improves Age-Related Testicular Dysfunction by Alleviating Sertoli Cell Injury via Upregulation of the ERα/Nrf2-Signaling Pathway

• Main Authors: Haixia Zhao (Author), Xu You (Author), Qian Chen (Author), Siqi Yang (Author), Qiongyan Ma (Author), Yumin He (Author), Chaoqi Liu (Author), Yaoyan Dun (Author), Jie Wu (Author), Changcheng Zhang (Author), Ding Yuan (Author)
• Format: Book
• Published: Frontiers Media S.A., 2020-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Sertoli cells play crucial roles in spermatogenesis and are impaired by aging. Icariin, a flavonoid from Epimedium, has been reported to exhibit anti-aging effects and improve testicular dysfunction in the clinical setting. However, whether icariin improves age-related degeneration of testicular fun...