Influence of different formulation variables on the performance of transdermal drug delivery system containing tizanidine hydrochloride: in vitro and ex vivo evaluations

• Main Authors: Maryam Shabbir (Author), Ali Sajid (Author), Irfan Hamid (Author), Ali Sharif (Author), Muhammad Furqan Akhtar (Author), Moosa Raza (Author), Shoaib Ahmed (Author), Sohaib Peerzada (Author), Muhammad Umair Amin (Author)
• Format: Book
• Published: Universidade de São Paulo, 2019-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The present study was aimed at preparation of transdermal patches of tizanidine HCl, evaluation of the effect of polymers on in vitro release pattern of the drug, and the effect of permeation enhancers on the penetration of the drug through the rabbit skin. Various proportions of hydrophilic (HPMC)...