Koumine Decreases Astrocyte-Mediated Neuroinflammation and Enhances Autophagy, Contributing to Neuropathic Pain From Chronic Constriction Injury in Rats

Koumine, an indole alkaloid, is a major bioactive component of Gelsemium elegans. Previous studies have demonstrated that koumine has noticeable anti-inflammatory and analgesic effects in inflammatory and neuropathic pain (NP) models, but the mechanisms involved are not well understood. This study w...

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Main Authors: Gui-lin Jin (Author), Rong-cai Yue (Author), Sai-di He (Author), Li-mian Hong (Author), Ying Xu (Author), Chang-xi Yu (Author)
Format: Book
Published: Frontiers Media S.A., 2018-08-01T00:00:00Z.
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