YY1-induced upregulation of LncRNA-ARAP1-AS2 and ARAP1 promotes diabetic kidney fibrosis via aberrant glycolysis associated with EGFR/PKM2/HIF-1α pathway

• Main Authors: Xin Li (Author), Tian-Kui Ma (Author), Min Wang (Author), Xiao-Dan Zhang (Author), Tian-Yan Liu (Author), Yue Liu (Author), Zhao-Hui Huang (Author), Yong-Hong Zhu (Author), Shuang Zhang (Author), Li Yin (Author), Yan-Yan Xu (Author), Hong Ding (Author), Cong Liu (Author), Hang Shi (Author), Qiu-Ling Fan (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objectives: Dimeric pyruvate kinase (PK) M2 (PKM2) plays an important role in promoting the accumulation of hypoxia-inducible factor (HIF)-1α, mediating aberrant glycolysis and inducing fibrosis in diabetic kidney disease (DKD). The aim of this work was to dissect a novel regulatory mechanism of Yin...