IL-17/Notch1/STAT3 Pathway Contributes to 5-Fluorouracil-Induced Intestinal Mucositis in Rats: Amelioration by Thymol Treatment

• Autores principales: Amira M. Badr (Autor), Layla A. Alkharashi (Autor), Iman O. Sherif (Autor), Alaa A. Alanteet (Autor), Hind N. Alotaibi (Autor), Yasmen F. Mahran (Autor)
• Formato: Libro
• Publicado: MDPI AG, 2022-11-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

5-Fluorouracil (5-FU) is an anticancer drug with intestinal mucositis (IM) as a deleterious side effect. Thymol is a monoterpene phenol which has been reported to possess an antioxidant and anti-inflammatory activity versus 5-FU-induced IM. The Notch pathway affects multiple cellular activities, suc...