In Vitro, In Vivo and In Silico Characterization of a Novel Kappa-Opioid Receptor Antagonist

In Vitro, In Vivo and In Silico Characterization of a Novel Kappa-Opioid Receptor Antagonist

Kappa-opioid receptor (KOR) antagonists are promising innovative therapeutics for the treatment of the central nervous system (CNS) disorders. The new scaffold opioid ligand, Compound A, was originally found as a mu-opioid receptor (MOR) antagonist but its binding/selectivity and activation profile...

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Main Authors: Kristina Puls (Author), Aina-Leonor (Author), Szymon Pach (Author), Birgit Pinter (Author), Filippo Erli (Author), Gerhard Wolber (Author), Mariana Spetea (Author)
Format: Book
Published: MDPI AG, 2022-05-01T00:00:00Z.
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