Acetylcholine Neurotransmitter Receptor Densities in the Striatum of Hemiparkinsonian Rats Following Botulinum Neurotoxin-A Injection
Cholinergic neurotransmission has a pivotal function in the caudate-putamen, and is highly associated with the pathophysiology of Parkinson's disease. Here, we investigated long-term changes in the densities of the muscarinic receptor subtypes M1, M2, M3 (mAchRs) and the nicotinic receptor subt...
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Frontiers Media S.A.,
2018-08-01T00:00:00Z.
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| 001 | doaj_fd0b51a3c8134456a8391560cbcec44d | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Teresa Mann |e author |
| 700 | 1 | 0 | |a Karl Zilles |e author |
| 700 | 1 | 0 | |a Karl Zilles |e author |
| 700 | 1 | 0 | |a Karl Zilles |e author |
| 700 | 1 | 0 | |a Felix Klawitter |e author |
| 700 | 1 | 0 | |a Markus Cremer |e author |
| 700 | 1 | 0 | |a Alexander Hawlitschka |e author |
| 700 | 1 | 0 | |a Nicola Palomero-Gallagher |e author |
| 700 | 1 | 0 | |a Nicola Palomero-Gallagher |e author |
| 700 | 1 | 0 | |a Oliver Schmitt |e author |
| 700 | 1 | 0 | |a Andreas Wree |e author |
| 245 | 0 | 0 | |a Acetylcholine Neurotransmitter Receptor Densities in the Striatum of Hemiparkinsonian Rats Following Botulinum Neurotoxin-A Injection |
| 260 | |b Frontiers Media S.A., |c 2018-08-01T00:00:00Z. | ||
| 500 | |a 1662-5129 | ||
| 500 | |a 10.3389/fnana.2018.00065 | ||
| 520 | |a Cholinergic neurotransmission has a pivotal function in the caudate-putamen, and is highly associated with the pathophysiology of Parkinson's disease. Here, we investigated long-term changes in the densities of the muscarinic receptor subtypes M1, M2, M3 (mAchRs) and the nicotinic receptor subtype α4β2 (nAchRs) in the striatum of the 6-OHDA-induced hemiparkinsonian (hemi-PD) rat model using quantitative in vitro receptor autoradiography. Hemi-PD rats exhibited an ipsilateral decrease in striatal mAchR densities between 6 and 16%. Moreover, a massive and constant decrease in striatal nAchR density by 57% was found. A second goal of the study was to disclose receptor-related mechanisms for the positive motor effect of intrastriatally injected Botulinum neurotoxin-A (BoNT-A) in hemi-PD rats in the apomorphine rotation test. Therefore, the effect of intrastriatally injected BoNT-A in control and hemi-PD rats on mAchR and nAchR densities was analyzed and compared to control animals or vehicle-injected hemi-PD rats. BoNT-A administration slightly reduced interhemispheric differences of mAchR and nAchR densities in hemi-PD rats. Importantly, the BoNT-A effect on striatal nAchRs significantly correlated with behavioral testing after apomorphine application. This study gives novel insights of 6-OHDA-induced effects on striatal mAchR and nAchR densities, and partly explains the therapeutic effect of BoNT-A in hemi-PD rats on a cellular level. | ||
| 546 | |a EN | ||
| 690 | |a receptors | ||
| 690 | |a acetylcholine | ||
| 690 | |a hemiparkinsonian rat model | ||
| 690 | |a Botulinum neurotoxin-A | ||
| 690 | |a basal ganglia | ||
| 690 | |a Parkinson's disease | ||
| 690 | |a Neurosciences. Biological psychiatry. Neuropsychiatry | ||
| 690 | |a RC321-571 | ||
| 690 | |a Human anatomy | ||
| 690 | |a QM1-695 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Frontiers in Neuroanatomy, Vol 12 (2018) | |
| 787 | 0 | |n https://www.frontiersin.org/article/10.3389/fnana.2018.00065/full | |
| 787 | 0 | |n https://doaj.org/toc/1662-5129 | |
| 856 | 4 | 1 | |u https://doaj.org/article/fd0b51a3c8134456a8391560cbcec44d |z Connect to this object online. |