Efficacy of Apremilast Gels in Mouse Model of Imiquimod-Induced Psoriasis Skin Inflammation

• Main Authors: Marcelle Silva-Abreu (Author), Lilian Sosa (Author), Lupe Carolina Espinoza (Author), María-José Fábrega (Author), María J. Rodríguez-Lagunas (Author), Mireia Mallandrich (Author), Ana Cristina Calpena (Author), María Luisa Garduño-Ramírez (Author), María Rincón (Author)
• Format: Book
• Published: MDPI AG, 2023-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Apremilast (APM) is a novel drug for the treatment of psoriasis and psoriatic arthritis. APM is a phosphodiesterase 4 (PDE4) inhibitor, raising intracellular cAMP levels and thereby decreasing the inflammatory response by modulating the expression of TNF-α, IL-17, IL-23, and other inflammatory cytok...