Efficacy of Apremilast Gels in Mouse Model of Imiquimod-Induced Psoriasis Skin Inflammation

• Autores principales: Marcelle Silva-Abreu (Autor), Lilian Sosa (Autor), Lupe Carolina Espinoza (Autor), María-José Fábrega (Autor), María J. Rodríguez-Lagunas (Autor), Mireia Mallandrich (Autor), Ana Cristina Calpena (Autor), María Luisa Garduño-Ramírez (Autor), María Rincón (Autor)
• Formato: Libro
• Publicado: MDPI AG, 2023-09-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

Apremilast (APM) is a novel drug for the treatment of psoriasis and psoriatic arthritis. APM is a phosphodiesterase 4 (PDE4) inhibitor, raising intracellular cAMP levels and thereby decreasing the inflammatory response by modulating the expression of TNF-α, IL-17, IL-23, and other inflammatory cytok...