Targeting a cryptic allosteric site of SIRT6 with small-molecule inhibitors that inhibit the migration of pancreatic cancer cells

• Main Authors: Qiufen Zhang (Author), Yingyi Chen (Author), Duan Ni (Author), Zhimin Huang (Author), Jiacheng Wei (Author), Li Feng (Author), Jun-Cheng Su (Author), Yingqing Wei (Author), Shaobo Ning (Author), Xiuyan Yang (Author), Mingzhu Zhao (Author), Yuran Qiu (Author), Kun Song (Author), Zhengtian Yu (Author), Jianrong Xu (Author), Xinyi Li (Author), Houwen Lin (Author), Shaoyong Lu (Author), Jian Zhang (Author)
• Format: Book
• Published: Elsevier, 2022-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

SIRT6 belongs to the conserved NAD+-dependent deacetylase superfamily and mediates multiple biological and pathological processes. Targeting SIRT6 by allosteric modulators represents a novel direction for therapeutics, which can overcome the selectivity problem caused by the structural similarity of...