PPARG in osteocytes controls cell bioenergetics and systemic energy metabolism independently of sclerostin levels in circulation

• Main Authors: Sudipta Baroi (Author), Piotr J. Czernik (Author), Mohd Parvez Khan (Author), Joshua Letson (Author), Emily Crowe (Author), Amit Chougule (Author), Patrick R. Griffin (Author), Clifford J. Rosen (Author), Beata Lecka-Czernik (Author)
• Format: Book
• Published: Elsevier, 2024-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: The skeleton is one of the largest organs in the body, wherein metabolism is integrated with systemic energy metabolism. However, the bioenergetic programming of osteocytes, the most abundant bone cells coordinating bone metabolism, is not well defined. Here, using a mouse model with part...