High-Efficacy α,β-Dehydromonacolin S Improves Hepatic Steatosis and Suppresses Gluconeogenesis Pathway in High-Fat Diet-Induced Obese Rats

• Main Authors: Jutatip Kaewmalee (Author), Atcharaporn Ontawong (Author), Acharaporn Duangjai (Author), Chittreeya Tansakul (Author), Vatcharin Rukachaisirikul (Author), Chatchai Muanprasat (Author), Chutima Srimaroeng (Author)
• Format: Book
• Published: MDPI AG, 2021-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Isolated α,β-dehydromonacolin S (<i>C5</i>) from soil-derived fungus <i>Aspergillus sclerotiorum</i> PSU-RSPG178 was recently shown to exhibit an inhibitory effect against 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGR) activity in vitro. In this study, we investigated...