Pleiotropic actions of IP6K1 mediate hepatic metabolic dysfunction to promote nonalcoholic fatty liver disease and steatohepatitis

• Main Authors: Sandip Mukherjee (Author), Molee Chakraborty (Author), Barbara Ulmasov (Author), Kyle McCommis (Author), Jinsong Zhang (Author), Danielle Carpenter (Author), Eliwaza Naomi Msengi (Author), Jake Haubner (Author), Chun Guo (Author), Daniel P. Pike (Author), Sarbani Ghoshal (Author), David A. Ford (Author), Brent A. Neuschwander-Tetri (Author), Anutosh Chakraborty (Author)
• Format: Book
• Published: Elsevier, 2021-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Obesity and insulin resistance greatly increase the risk of nonalcoholic fatty liver disease and steatohepatitis (NAFLD/NASH). We have previously discovered that whole-body and adipocyte-specific Ip6k1deletion protects mice from high-fat-diet-induced obesity and insulin resistance due to...