Protective effect of microbiota-derived short chain fatty acids on vascular dysfunction in mice with systemic lupus erythematosus induced by toll like receptor 7 activation

• Main Authors: Javier Moleón (Author), Cristina González-Correa (Author), Sofía Miñano (Author), Iñaki Robles-Vera (Author), Néstor de la Visitación (Author), Antonio Manuel Barranco (Author), Manuel Gómez-Guzmán (Author), Manuel Sánchez (Author), Pedro Riesco (Author), Eduardo Guerra-Hernández (Author), Marta Toral (Author), Miguel Romero (Author), Juan Duarte (Author)
• Format: Book
• Published: Elsevier, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Our objective was to investigate whether short-chain fatty acids (SCFAs), specifically acetate and butyrate, could prevent vascular dysfunction and elevated blood pressure (BP) in mice with systemic lupus erythematosus (SLE) induced by TLR7 activation using imiquimod (IMQ). Treatment with both SCFAs...