Predicting complex kidney drug handling using a physiologically‐based pharmacokinetic model informed by biomarker‐estimated secretory clearance and blood flow

• Auteurs principaux: Michael L. Granda (Auteur), Weize Huang (Auteur), Catherine K. Yeung (Auteur), Nina Isoherranen (Auteur), Bryan Kestenbaum (Auteur)
• Format: Livre
• Publié: Wiley, 2024-01-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

Abstract Kidney function‐adjusted drug dosing is currently based solely on the estimated glomerular filtration rate (GFR), however, kidney drug handling is accomplished by a combination of filtration, tubular secretion, and re‐absorption. Mechanistic physiologically‐based pharmacokinetic (PBPK) mode...