Predicting complex kidney drug handling using a physiologically‐based pharmacokinetic model informed by biomarker‐estimated secretory clearance and blood flow

• Những tác giả chính: Michael L. Granda (Tác giả), Weize Huang (Tác giả), Catherine K. Yeung (Tác giả), Nina Isoherranen (Tác giả), Bryan Kestenbaum (Tác giả)
• Định dạng: Sách
• Được phát hành: Wiley, 2024-01-01T00:00:00Z.
• Những chủ đề: article
• Truy cập trực tuyến: Connect to this object online.

Abstract Kidney function‐adjusted drug dosing is currently based solely on the estimated glomerular filtration rate (GFR), however, kidney drug handling is accomplished by a combination of filtration, tubular secretion, and re‐absorption. Mechanistic physiologically‐based pharmacokinetic (PBPK) mode...