Predicting complex kidney drug handling using a physiologically‐based pharmacokinetic model informed by biomarker‐estimated secretory clearance and blood flow
Abstract Kidney function‐adjusted drug dosing is currently based solely on the estimated glomerular filtration rate (GFR), however, kidney drug handling is accomplished by a combination of filtration, tubular secretion, and re‐absorption. Mechanistic physiologically‐based pharmacokinetic (PBPK) mode...
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| Main Authors: | , , , , |
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| Format: | Book |
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Wiley,
2024-01-01T00:00:00Z.
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Internet
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| Call Number: |
A1234.567 |
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| Copy 1 | Available |