Predicting complex kidney drug handling using a physiologically‐based pharmacokinetic model informed by biomarker‐estimated secretory clearance and blood flow

• প্রধান লেখক: Michael L. Granda (লেখক), Weize Huang (লেখক), Catherine K. Yeung (লেখক), Nina Isoherranen (লেখক), Bryan Kestenbaum (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: Wiley, 2024-01-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

Abstract Kidney function‐adjusted drug dosing is currently based solely on the estimated glomerular filtration rate (GFR), however, kidney drug handling is accomplished by a combination of filtration, tubular secretion, and re‐absorption. Mechanistic physiologically‐based pharmacokinetic (PBPK) mode...