Deficiency of α7 Nicotinic Acetylcholine Receptor Attenuates Bleomycin-Induced Lung Fibrosis in Mice

• Main Authors: Peiyu Sun (Author), Ling Li (Author), Caiqi Zhao (Author), Mengyao Pan (Author), Zhikang Qian (Author), Xiao Su (Author)
• 格式: 图书
• 出版: BMC, 2017-03-01T00:00:00Z.
• 主题: article
• 在线阅读: Connect to this object online.

Abstract α7 nicotinic acetylcholine receptor (α7 nAChR, coded by Chrna7) is indispensable in dampening proinflammatory responses. However, whether α7 nAChR plays a role in regulating bleomycin (BLM)-induced lung fibrosis is less investigated. Here, we challenged wild-type and Chrna7−/− mice with BLM...