Subtoxic Concentrations of Hepatotoxic Drugs Lead to Kupffer Cell Activation in a Human In Vitro Liver Model: An Approach to Study DILI

• Main Authors: Victoria Kegel (Author), Elisa Pfeiffer (Author), Britta Burkhardt (Author), Jia L. Liu (Author), Katrin Zeilinger (Author), Andreas K. Nüssler (Author), Daniel Seehofer (Author), Georg Damm (Author)
• Format: Book
• Published: Hindawi Limited, 2015-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Drug induced liver injury (DILI) is an idiosyncratic adverse drug reaction leading to severe liver damage. Kupffer cells (KC) sense hepatic tissue stress/damage and therefore could be a tool for the estimation of consequent effects associated with DILI. Aim of the present study was to establish a hu...