Poldip2 knockdown protects against lipopolysaccharide-induced acute lung injury via Nox4/Nrf2/NF-κB signaling pathway

• Main Authors: Yueguo Wang (Author), Wenwen Wang (Author), Shusheng Zhou (Author), Yulan Wang (Author), Obed Cudjoe (Author), Yu Cha (Author), Chunyan Wang (Author), Xiaoguang Cao (Author), Wei Liu (Author), Kui Jin (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Polymerase δ-interacting protein 2 (Poldip2) has been reported to mediate acute lung injury (ALI); however, the underlying mechanism is not fully explored. Male C57BL/6 mice and A549 cells were used to establish the lipopolysaccharide (LPS)-induced ALI model, then the expression of Poldip2 and its e...