Gel-Free Tools for Quick and Simple Screening of Anti-Topoisomerase 1 Compounds

• Main Authors: Josephine Geertsen Keller (Author), Kamilla Vandsø Petersen (Author), Karol Mizielinski (Author), Celine Thiesen (Author), Lotte Bjergbæk (Author), Rosa M. Reguera (Author), Yolanda Pérez-Pertejo (Author), Rafael Balaña-Fouce (Author), Angela Trejo (Author), Carme Masdeu (Author), Concepcion Alonso (Author), Birgitta R. Knudsen (Author), Cinzia Tesauro (Author)
• Format: Book
• Published: MDPI AG, 2023-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

With the increasing need for effective compounds against cancer or pathogen-borne diseases, the development of new tools to investigate the enzymatic activity of biomarkers is necessary. Among these biomarkers are DNA topoisomerases, which are key enzymes that modify DNA and regulate DNA topology du...