Diagnostic and prognostic role of NLR in testicular cancer

Background: To summarize the results of available studies for investigating the role of neutrophil to lymphocyte ratio (NLR) in testicular cancer (tCa). Methods: The search was conducted on PubMed, Scopus, and Web of Science up to November 21, 2021. Finally, a total of 31 studies were included in th...

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Main Authors: Shirin Sarejloo (Author), Saghar Babadi (Author), Shokoufeh Khanzadeh (Author), Amirhossein Salimi (Author), Alec Clark (Author), Dinyar Khazaeli (Author), Monireh Khanzadeh (Author), Arshin Ghaedi (Author), Brandon Lucke-Wold (Author)
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Published: Open Exploration Publishing Inc., 2024-09-01T00:00:00Z.
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042 |a dc 
100 1 0 |a Shirin Sarejloo  |e author 
700 1 0 |a Saghar Babadi  |e author 
700 1 0 |a Shokoufeh Khanzadeh  |e author 
700 1 0 |a Amirhossein Salimi  |e author 
700 1 0 |a Alec Clark  |e author 
700 1 0 |a Dinyar Khazaeli  |e author 
700 1 0 |a Monireh Khanzadeh  |e author 
700 1 0 |a Arshin Ghaedi  |e author 
700 1 0 |a Brandon Lucke-Wold  |e author 
245 0 0 |a Diagnostic and prognostic role of NLR in testicular cancer 
260 |b Open Exploration Publishing Inc.,   |c 2024-09-01T00:00:00Z. 
500 |a 10.37349/etat.2024.00270 
500 |a 2692-3114 
520 |a Background: To summarize the results of available studies for investigating the role of neutrophil to lymphocyte ratio (NLR) in testicular cancer (tCa). Methods: The search was conducted on PubMed, Scopus, and Web of Science up to November 21, 2021. Finally, a total of 31 studies were included in this review. Results: NLR was higher in tCa patients compared to healthy controls and benign testis pathologies, and decreased significantly after orchiectomy. An elevated NLR predicts poor prognosis, advanced stage, presence of nodal or distant metastases, contralateral tumor development, lower time-to-cancer specific death, worse OS, and poorer response to chemotherapy. However, NLR could not differentiate between seminomas and non-seminomatous tCa. Discussion: NLR has a significant diagnostic and prognostic value in tCa. 
546 |a EN 
690 |a neutrophil to lymphocyte ratio 
690 |a testicular cancer 
690 |a systematic review 
690 |a Internal medicine 
690 |a RC31-1245 
655 7 |a article  |2 local 
786 0 |n Exploration of Targeted Anti-tumor Therapy, Vol 5, Iss 6, Pp 1177-1198 (2024) 
787 0 |n https://www.explorationpub.com/Journals/etat/Article/1002270 
787 0 |n https://doaj.org/toc/2692-3114 
856 4 1 |u https://doaj.org/article/fd2f09cccc2a4ddab927a05550cf9009  |z Connect to this object online.