Toward enhancement of antibody thermostability and affinity by computational design in the absence of antigen

• Main Authors: Mark Hutchinson (Author), Jeffrey A. Ruffolo (Author), Nantaporn Haskins (Author), Michael Iannotti (Author), Giuliana Vozza (Author), Tony Pham (Author), Nurjahan Mehzabeen (Author), Harini Shandilya (Author), Keith Rickert (Author), Rebecca Croasdale-Wood (Author), Melissa Damschroder (Author), Ying Fu (Author), Andrew Dippel (Author), Jeffrey J. Gray (Author), Gilad Kaplan (Author)
• Format: Book
• Published: Taylor & Francis Group, 2024-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Over the past two decades, therapeutic antibodies have emerged as a rapidly expanding domain within the field of biologics. In silico tools that can streamline the process of antibody discovery and optimization are critical to support a pipeline that is growing more numerous and complex every year....