A Synthetic Small Molecule, LGM2605: A Promising Modulator of Increased Pro-Inflammatory Cytokine and Osteoclast Differentiation by <i>Aggregatibacter actinomycetemcomitans</i> Cytolethal Distending Toxin

A Synthetic Small Molecule, LGM2605: A Promising Modulator of Increased Pro-Inflammatory Cytokine and Osteoclast Differentiation by <i>Aggregatibacter actinomycetemcomitans</i> Cytolethal Distending Toxin

Our research explores the interplay between <i>Aggregatibacter actinomycetemcomitans</i> (<i>Aa</i>) cytolethal distending toxin (Cdt) and the host's inflammatory response in molar/incisor pattern periodontitis (MIPP). Cdt disrupts phosphatidylinositol-3,4,5-triphosphate...

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Main Authors: Taewan J. Kim (Author), Andrew S. MacElroy (Author), Aleena Defreitas (Author), Bruce J. Shenker (Author), Kathleen Boesze-Battaglia (Author)
Format: Book
Published: MDPI AG, 2024-06-01T00:00:00Z.
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