Human monocytes differentiate into tumor-associated macrophages upon SKOV3 cells coculture and/or lysophosphatidic acid stimulation

• Main Authors: Ying Feng (Author), Meizhu Xiao (Author), Guangming Cao (Author), Hao Liu (Author), Yanfang Li (Author), Shuzhen Wang (Author), Stan Zijtveld (Author), Bert Delvoux (Author), Sofia Xanthoulea (Author), Andrea Romano (Author), Chongdong Liu (Author), Zhenyu Zhang (Author)
• Format: Book
• Published: BMC, 2022-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Serous ovarian carcinoma is the most common type of ovarian carcinoma. Tumor-associated macrophages (TAMs) promote ovarian cancer progression. Most macrophages are generated by monocyte differentiation. Lysophosphatidic acid (LPA) levels are high in blood, tissues and ascites of...