Severe Atopic Dermatitis In Spain: A Real-Life Observational Study

• Main Authors: Sicras-Mainar A (Author), Navarro-Artieda R (Author), Armario-Hita JC (Author)
• Format: Book
• Published: Dove Medical Press, 2019-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

Antoni Sicras-Mainar,1 Ruth Navarro-Artieda,2 Jos&eacute; C Armario-Hita3 1Scientific Direction, Real Life Data, Madrid, Spain; 2Medical Documentation, Germans Trias i Pujol Hospital, Barcelona, Spain; 3Dermatology Service, Puerto Real University Hospital, Cadiz University, C&aacute;diz, SpainCorrespondence: Antoni Sicras-MainarScientific Direction, Real Life Data, c/Cronos, 24&ndash;26, P3 - Bajo E36, Madrid 08037, SpainTel [phone]Email [e-mail]: To determine the epidemiology and characterize the treatment prescribed for severe atopic dermatitis (AD) in children/adults in usual clinical practice.Methods: Observational, retrospective study made through review of medical records of Spanish patients aged &ge;6 years. Patients diagnosed with severe AD who required care between 2013 and 2017 were included. The study groups were: 6&ndash;12 years; 13&ndash;18 years; and > 18 years. Patients were followed for 5 years. The main measurements were the prevalence of AD, comorbidity and treatment duration. Statistical significance was established as p <0.05.Results: We included 2323 patients with severe AD. The overall prevalence was 0.10% (95% CI: 0.09&ndash;0.11%) and was 0.39%, 0.23% and 0.07% in the 6&ndash;12 years, 13&ndash;18 years and >18 years age groups, respectively (p <0.001), the percentage of males was 58%, 48.6% and 39%, respectively, and general comorbidity was 0.1, 0.2 and 0.9 points, respectively (p <0.001).The most frequent comorbidities were asthma in 49.0%, 44.9% and 20.8%, respectively (p <0.001), and anxiety in 79.7%, 65.8% and 67.3%, respectively (p <0.001). Oral corticosteroids were administered in 97.3%, 90.9% and 81.7%, respectively (concomitant-medication). Cyclosporine (45.3%), azathioprine (15.9%) and methotrexate (9.0%) were the most frequently prescribed drugs; biologic agents were administered in 5.8% of patients (for AD).Conclusion: In AD the presence of comorbidities was significant, especially in the psychological, immunoallergic and cardiovascular areas. Cyclosporine was the most widely used immunosuppressant. There was a degree of variability in the use and duration of the treatments prescribed.Keywords: severe atopic dermatitis, epidemiology, comorbidity, treatment, immunosuppressants, biologics

Item Description

1178-203X