Enhancement of solubility and dissolution rate of poorly water soluble raloxifene using microwave induced fusion method

• Main Authors: Payal Hasmukhlal Patil (Author), Veena Sailendra Belgamwar (Author), Pratibha Ramratan Patil (Author), Sanjay Javerilal Surana (Author)
• Format: Book
• Published: Universidade de São Paulo, 2013-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The objective of the present work was to enhance the solubility and dissolution rate of the drug raloxifene HCl (RLX), which is poorly soluble in water. The solubility of RLX was observed to increase with increasing concentration of hydroxypropyl methylcellulose (HPMC E5 LV). The optimized ratio for...