Discovery of novel, orally bioavailable, antileishmanial compounds using phenotypic screening.

• Main Authors: Diana Ortiz (Author), W Armand Guiguemde (Author), Jared T Hammill (Author), Angela K Carrillo (Author), Yizhe Chen (Author), Michele Connelly (Author), Kayla Stalheim (Author), Carolyn Elya (Author), Alex Johnson (Author), Jaeki Min (Author), Anang Shelat (Author), David C Smithson (Author), Lei Yang (Author), Fangyi Zhu (Author), R Kiplin Guy (Author), Scott M Landfear (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2017-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Leishmaniasis is a parasitic infection that afflicts approximately 12 million people worldwide. There are several limitations to the approved drug therapies for leishmaniasis, including moderate to severe toxicity, growing drug resistance, and the need for extended dosing. Moreover, miltefosine is c...