Downregulation of miR-146a Contributes to Cardiac Dysfunction Induced by the Tyrosine Kinase Inhibitor Sunitinib

• Những tác giả chính: Li Shen (Tác giả), Congxin Li (Tác giả), Hua Zhang (Tác giả), Suhua Qiu (Tác giả), Tian Fu (Tác giả), Yanfang Xu (Tác giả)
• Định dạng: Sách
• Được phát hành: Frontiers Media S.A., 2019-08-01T00:00:00Z.
• Những chủ đề: article
• Truy cập trực tuyến: Connect to this object online.

The main adverse effect of tyrosine kinase inhibitors, such as sunitinib, is cardiac contractile dysfunction; however, the molecular mechanisms of this effect remain largely obscure. MicroRNAs (miRNAs) are key regulatory factors in both cardiovascular diseases and the tyrosine kinase pathway. Theref...