Structural modeling of hERG channel-drug interactions using Rosetta

• Main Authors: Aiyana M. Emigh Cortez (Author), Kevin R. DeMarco (Author), Kazuharu Furutani (Author), Slava Bekker (Author), Jon T. Sack (Author), Heike Wulff (Author), Colleen E. Clancy (Author), Igor Vorobyov (Author), Vladimir Yarov-Yarovoy (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The human ether-a-go-go-related gene (hERG) not only encodes a potassium-selective voltage-gated ion channel essential for normal electrical activity in the heart but is also a major drug anti-target. Genetic hERG mutations and blockage of the channel pore by drugs can cause long QT syndrome, which...