Enhancement in antinociceptive and anti-inflammatory effects of tramadol by transdermal proniosome gel

• Main Authors: Jigar Shah (Author), Anroop B. Nair (Author), Hiral Shah (Author), Shery Jacob (Author), Tamer M. Shehata (Author), Mohamed Aly Morsy (Author)
• Format: Book
• Published: Elsevier, 2020-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Oral therapy of tramadol, an opiate analgesic, undergoes extensive hepatic metabolism and requires frequent administration. Transdermal therapy by virtue can overcome these issues and can improve the efficacy and reduce abuse liability of tramadol. The aim of this research was to investigate the pos...