MCL-1 Inhibitor S63845 Distinctively Affects Intramedullary and Extramedullary Hematopoiesis

• Main Authors: Hexiao Zhang (Author), Fei Li (Author), Ming Yang (Author), Wenshan Zhang (Author), Mei He (Author), Hui Xu (Author), Chaoqun Wang (Author), Yiran Zhang (Author), Wei Wang (Author), Yingdai Gao (Author), Xue Du (Author), Yinghui Li (Author)
• Format: Book
• Published: MDPI AG, 2023-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Conventional chemotherapy for killing cancer cells using cytotoxic drugs suffers from low selectivity, significant toxicity, and a narrow therapeutic index. Hyper-specific targeted drugs achieve precise destruction of tumors by inhibiting molecular pathways that are critical to tumor growth. Myeloid...