A matrix of structure-based designs yields improved VRC01-class antibodies for HIV-1 therapy and prevention

• প্রধান লেখক: Young D. Kwon (লেখক), Mangaiarkarasi Asokan (লেখক), Jason Gorman (লেখক), Baoshan Zhang (লেখক), Qingbo Liu (লেখক), Mark K. Louder (লেখক), Bob C. Lin (লেখক), Krisha McKee (লেখক), Amarendra Pegu (লেখক), Raffaello Verardi (লেখক), Eun Sung Yang (লেখক), VRC Production Program (লেখক), Kevin Carlton (লেখক), Nicole A. Doria-Rose (লেখক), Paolo Lusso (লেখক), John R. Mascola (লেখক), Peter D. Kwong (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

Passive transfer of broadly neutralizing antibodies is showing promise in the treatment and prevention of HIV-1. One class of antibodies, the VRC01 class, appears especially promising. To improve VRC01-class antibodies, we combined structure-based design with a matrix-based approach to generate VRC0...