A matrix of structure-based designs yields improved VRC01-class antibodies for HIV-1 therapy and prevention

• Main Authors: Young D. Kwon (Author), Mangaiarkarasi Asokan (Author), Jason Gorman (Author), Baoshan Zhang (Author), Qingbo Liu (Author), Mark K. Louder (Author), Bob C. Lin (Author), Krisha McKee (Author), Amarendra Pegu (Author), Raffaello Verardi (Author), Eun Sung Yang (Author), VRC Production Program (Author), Kevin Carlton (Author), Nicole A. Doria-Rose (Author), Paolo Lusso (Author), John R. Mascola (Author), Peter D. Kwong (Author)
• Format: Book
• Published: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Passive transfer of broadly neutralizing antibodies is showing promise in the treatment and prevention of HIV-1. One class of antibodies, the VRC01 class, appears especially promising. To improve VRC01-class antibodies, we combined structure-based design with a matrix-based approach to generate VRC0...