Layer‐by‐layer nanoparticles for novel delivery of cisplatin and PARP inhibitors for platinum‐based drug resistance therapy in ovarian cancer

• Main Authors: Lawrence B. Mensah (Author), Stephen W. Morton (Author), Jiahe Li (Author), Haihua Xiao (Author), Mohiuddin A. Quadir (Author), Kevin M. Elias (Author), Emily Penn (Author), Aysen K. Richson (Author), Paiman Peter Ghoroghchian (Author), Joyce Liu (Author), Paula T. Hammond (Author)
• Format: Book
• Published: Wiley, 2019-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Advanced staged high‐grade serous ovarian cancer (HGSOC) is the leading cause of gynecological cancer death in the developed world, with 5‐year survival rates of only 25-30% due to late‐stage diagnosis and the shortcomings of platinum‐based therapies. A Phase I clinical trial of a combinati...