Imatinib induces diastolic dysfunction and ventricular early-repolarization delay in the halothane-anesthetized dogs: Class effects of tyrosine kinase inhibitors

• Main Authors: Koki Chiba (Author), Ryuichi Kambayashi (Author), Mayu Onozato (Author), Ai Goto (Author), Hiroko Izumi-Nakaseko (Author), Yoshinori Takei (Author), Akio Matsumoto (Author), Koichiro Tanaka (Author), Yasunari Kanda (Author), Takeshi Fukushima (Author), Atsushi Sugiyama (Author)
• Format: Book
• Published: Elsevier, 2022-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Imatinib has been reported to induce heart failure and/or QTc prolongation. To better understand their underlying mechanisms, we assessed its effects on cardiohemodynamic, electrocardiographic and echocardiographic variables along with biomarkers of myocardial damage. Imatinib mesylate in doses of 1...