Structure-function and rational design of a spider toxin Ssp1a at human voltage-gated sodium channel subtypes

• Main Authors: Yashad Dongol (Author), David T. Wilson (Author), Norelle L. Daly (Author), Fernanda C. Cardoso (Author), Richard J. Lewis (Author)
• 格式: 圖書
• 出版: Frontiers Media S.A., 2023-11-01T00:00:00Z.
• 主題: article
• 在線閱讀: Connect to this object online.

The structure-function and optimization studies of NaV-inhibiting spider toxins have focused on developing selective inhibitors for peripheral pain-sensing NaV1.7. With several NaV subtypes emerging as potential therapeutic targets, structure-function analysis of NaV-inhibiting spider toxins at such...