Ex vivo Culture of Duodenal Biopsies from Patients with Dermatitis Herpetiformis Indicates that Transglutaminase 3 Antibody Production Occurs in the Gut

• Main Authors: Minna Hietikko (Author), Kaisa Hervonen (Author), Tuire Ilus (Author), Teea Salmi (Author), Heini Huhtala (Author), Kaija Laurila (Author), Tiina Rauhavirta (Author), Timo Reunala (Author), Katri Kaukinen (Author), Katri Lindfors (Author)
• Format: Book
• Published: Medical Journals Sweden, 2017-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Coeliac disease and dermatitis herpetiformis (DH) are characterized by autoantibodies targeting transglutaminase (TG)2 and TG3, respectively. Previous studies show that TG2 antibodies are produced in the gut and can be assessed in organ culture of small-intestinal biopsies from patients with coeliac...