Commercialization of the Xalkori Pediatric Multiparticulate Product Using Quality-by-Design Principles

• Main Authors: Jeremy Bartlett (Author), Natalie Culver (Author), Xiang Zhang (Author), Brett Waybrant (Author), Hannah Sullivan (Author), Logan Howell (Author)
• Format: Book
• Published: MDPI AG, 2024-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A pediatric dosage form for crizotinib (Xalkori) was commercialized using quality-by-design principles in a material-sparing fashion. The dosage form consists of spherical multiparticulates (microspheres or pellets) that are coated and encapsulated in capsules for opening. The crizotinib (Xalkori)-c...