Therapeutic knockdown of miR-320 improves deteriorated cardiac function in a pre-clinical model of non-ischemic diabetic heart disease

• Main Authors: Nilanjan Ghosh (Author), Sonya Fenton (Author), Isabelle van Hout (Author), Gregory T. Jones (Author), Sean Coffey (Author), Michael J.A. Williams (Author), Ramanen Sugunesegran (Author), Dominic Parry (Author), Philip Davis (Author), Daryl O. Schwenke (Author), Anirudha Chatterjee (Author), Rajesh Katare (Author)
• Format: Book
• Published: Elsevier, 2022-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Non-ischemic diabetic heart disease (NiDHD) is characterized by diastolic dysfunction and decreased or preserved systolic function, eventually resulting in heart failure. Accelerated apoptotic cell death because of alteration of molecular signaling pathways due to dysregulation in microRNAs (miRNAs)...