Analysis of factor V Leiden and prothrombin mutations in patients with suspected thrombophilia in São Paulo state-Brazil

• Main Authors: Marcos Edgar Herkenhoff (Author), Rodrigo Gaulke (Author), Vanessa Rosália Remualdo (Author), Carlos André da Veiga Lima Rosa (Author)
• Format: Book
• Published: Sociedade Brasileira de Patologia Clínica, 2013-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

INTRODUCTION: Prothrombin (factor II) is a thrombin precursor, which induces fibrin formation. A mutation in the prothrombin gene (G20210A) has been described, which is directly associated with high prothrombin levels, hence thrombophilia. G1691A mutation in the factor V Leiden (FVL) gene occurs on...